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Although some genes that were typically associated with ISR and cholesterol and FA biosynthesis were also upregulated and downregulated, respectively, in Cse / mice on a no-Trp diet in comparison to Cse +/ and Cse / mice on the control diet, their induction on the no-Cys diet was significantly more pronounced, underscoring a special role of cysteine in the regulation of ISR and fat metabolism (Fig

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Karthivashan, I.S

Role of nicotinamide adenine dinucleotide and related precursors as therapeutic targets for age-related degenerative diseases: rationale, biochemistry, pharmacokinetics, and outcomes

[DOI] [PMC free article] [PubMed] [Google Scholar] 79.Gao Y, Vidal-Itriago A, Kalsbeek MJ, Layritz C, Garcia-Caceres C, Tom RZ, Eichmann TO, Vaz FM, Houtkooper RH, Van der Wel N, et al