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Theoretically, combining MOTS-c with a GLP-1 agonist (like semaglutide or tirzepatide) could produce synergistic effects

BPC-157 significantly enhances ERK1/2 phosphorylation in a dose-dependent manner, activating downstream targets including transcription factors c-Fos, c-Jun, and Egr-1

doi: 10.1093/geronj/11.3.298 [DOI] [PubMed] [Google Scholar] 9

[DOI] [PubMed] [Google Scholar] [66].Xu XM, Carlson BA, Mix H, Zhang Y, Saira K, Glass RS, Berry MJ, Gladyshev VN, Hatfield DL, Biosynthesis of selenocysteine on its tRNA in eukaryotes

It's not FDA-approved, but it's not explicitly banned for personal use in most jurisdictions