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Roflumilast in symptomatic chronic obstructive pulmonary disease: two randomised clinical trials
High glucose levels in diabetic patients affect the osteogenic differentiation of BMSCs, leading to osteoporosis

The impairment of KP in ALS is confirmed by the following evidence: higher serum tryptophan, cerebrospinal fluid (CSF), KYN and QA and a decrease in serum picolinic acid levels in ALS patients

These findings suggest that intravitreal injection of ET-1 immediately and dramatically reduced retinal BF, while AAV2-derived exogenous endothelin-1 chronically and gently reduced retinal BF, as in glaucoma patients