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Materials and Methods This extensive review consolidates literature published since the year 2000, providing a critical assessment of NACs neuromodulatory mechanisms and its therapeutic potential in various CNS disorders

Mechanistic insights from non-AD neuroinflammatory systems provide complementary evidence: interferon- (IFN-) robustly induces PD-L1 expression in human astrocytes and microglia, establishing a checkpointredox interface that suppresses excessive oxidative injury (Smith et al., 2023

However, the discovery of functional extrinsic death receptor-mediated eryptosis and necroptosis of erythrocytes associated with the necrosome formation opens new horizons for our understanding of the possible role of caspases in mature erythrocytes, since caspase-8 might be involved in coordinating the cell fate of mature erythrocytes

10.1126/science.256.5055.342 18

SOD is an endogenous antioxidant that rapidly reduces superoxide molecules to hydrogen peroxide [69, 109]