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The degradation of ACh in the body by AChE also maintains it at an appropriate level, which may be due to the regulatory function of the non-neural cholinergic system (NNCS) (117)

This reaction is catalyzed by two mitochondrial enzymes: 4-aminobutyrate-2-oxoglutarate transaminase (also known as GABA-T or -alanine-2-oxoglutarate transaminase) and alanine-glyoxylate transaminase (also called AGXT2 or -alanine-pyruvate transaminase) [44,45,46]

In addition, VEGFR-2 signaling has been shown to lead to Rho/ROCK activation which then affects downstream enzymes such as focal adhesion kinase (FAK) and transcription factors such as signal transducer and activator of transcription (STAT) (30, 223, 224)
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