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89 A double-blind, placebo-controlled study in veterans with post-traumatic stress disorder (PTSD) and SUD found a 48% decrease in depressive symptoms and a 32% decrease in self-reported PTSD symptoms, results that were significantly better than placebo (15% and 3%, respectively)

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Moreover, CpG islands in the promoter region of Oct4 gene were unmethylated in the transcriptionally active Oct4 of the ES and ES-cancer hybrids, but methylated in the silenced Oct4 of the adult cancer cells, further supporting that the reactivation of the silenced pluripotent gene (Figure 2d)

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