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10.1152/ajpheart.00554.2011 197 TsvetkovP.CoyS.PetrovaB.DreishpoonM.VermaA.AbdusamadM.et al (2022)

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This prolonged half-life comes from two key structural modifications

A role for the sphingosine kinase/sphingosine 1-phosphate axis
Some patients feel a difference within twenty-four hours
