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Although the precise pathogenic mechanisms remain to be fully elucidated, studies in non-DKD environments provide important clues

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A further longitudinal study estimated an incidence rate of 68 cases per 1000 person-years over 2.8 years, with higher risk observed among older patients, those with type 2 DM, and patients with autonomic and sensory neuropathy [14]

Diabetologia 63(10):2030-9 2020 PMC7646259 Hutto RA, Bisbach CM, Abbas F, Brock DC, Cleghorn WM, Parker ED, Bauer BH, Ge W, Vinberg F, Hurley JB, Brockerhoff SE

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