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Transient receptor potential (TRP) channels: biosensors for redox environmental stimuli and cellular status

10.1016/j.omtn.2022.03.020 7 ChenH.WangL.LiuJ.WanZ.ZhouL.LiaoH.et al (2023)

[DOI] [PMC free article] [PubMed] [Google Scholar] 26.Tarafdar A., Pula G

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Indeed translocation of mTORC1 from the cytoplasm to the lysosome, a rich compartment in amino acids, is critical for mTORC1 activation ( per se is also able to regulate mTORC1 activity ( In brief, activation of the GCN2-ATF4 amino acid stress pathway and inhibition of protein synthesis through inhibition of mTORC1 demonstrates the strong proteogenic role played by cysteine in tumor cells
