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Post hoc analysis of LEADER data revealed a persistent increase in the overall risk of biliary tract-related events and gallbladder diseases, consistently observed across four categories: uncomplicated gallbladder stones, complicated gallbladder stones, cholecystitis with/without gallbladder stones, and biliary obstruction [34]

These modifications may limit many methylation reactions, including reactions involving DNA and myelin basic protein

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Beyond heavy metals, other environmental contaminants such as fine particulate matter (PM2.5), pesticides, and industrial chemicals can also disrupt the structural integrity of the ECM and promote aberrant tissue remodeling [108,109]

Side Effects: While generally safe when used as directed, potential side effects include