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IDO activation can reduce tryptophan and increase toxic metabolites of the kynurenine pathway, which increases glial activation, neuroinflammation, toxicity, and neuronal death

[DOI] [PubMed] [Google Scholar] 9.Sikiric P., Drmic D., Sever M., Klicek R., Blagaic A.B., Tvrdeic A., Kralj T., Kovac K.K., Vukojevic J., Siroglavic M., et al

Lesser-known members like GPx5, GPx6, GPx7, and GPx8 often rely on cysteine and play niche roles, such as in sperm protection (GPx5) or endoplasmic reticulum stress management (GPx7 and GPx8)

(ii) contrasting the exacerbation of the inflammatory response

complemented by genetically encoded sensors for compartment-specific, real-time tracking and CRISPRCas systems for GSH-dependent genomic reporting, these integrated platforms collectively facilitate real-time monitoring, precise biomarker detection, and the development of redox-targeted therapies