central nervous system uptake of intranasal glutathione in parkinson's disease the Brain Chitosan-Based Nanoparticles for Nose-to-Brain Drug

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Together, these findings demonstrate that, in contrast with acute exposure, chronic disruption of iron homeostasis with consequent GSH depletion remodels cellular redox homeostasis over time, inducing a state we term chronoferroptosis: a persistent ferroptotic adaptation characterized by coordinated alterations in iron-handling and antioxidant defense proteins that may represent early vulnerability to neurodegenerative pathology

The direction is changing, but the change is not yet complete

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The KO sheep displayed a significant increase in fine-wool and active hair-follicle density