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This modification stimulates the catalytic activity of the enzyme, rendering it predominantly in a dimeric state (58)

Accordingly, a study showed that GSTP1 could upregulate the STAT3 to promote distance tissue and lymphatic metastasis, indicating its regulatory role in signaling pathways related to metastatic processes (Wang et al

Raw RNA sequencing and RRBS data have been deposited in NCBIs GEO database under accession nos

DHEA is another adrenal androgen and is mostly found in circulation as DHEA-S

15,73,75 The olfactory region is considered the main region for the nose-to-brain delivery and provides a direct route that involves mechanisms of extracellular/paracellular diffusion and intracellular absorption into the olfactory neurons