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These include immunogenicity associated with certain ligands, restricted tissue penetration due to the tumors dense extracellular matrix, and dynamic regulation of receptor expression that can hinder consistent targeting

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Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance

Since then, ADCs have emerged as a promising approach in oncology, with 15 ADCs approved globally by 2024

Oral NAC was effective in preventing oxaliplatin-induced mechanical and cold allodynia in mice and significantly reduced liver, kidney, and spinal cord peroxidation, kidney protein carbonylation, and spinal IL-1b and TNF- expression induced by oxaliplatin but did not affect the antitumor activity or hematological toxicity of oxaliplatin in vivo [62]