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Pitrat, M., Hanelt, P

In an observational study of individuals with chronic pain due to a variety of conditions who were unable to control their pain with usual therapies, adding 600 mg PEA twice daily for three weeks followed by once daily for another four weeks decreased average pain intensity scores in all participants who completed the study (Gatti 2012)

THC is distributed and metabolized in a region-specific manner, with highest levels in the hippocampus

2020;238 doi: 10.1016/j.carbpol.2020.116196

12R-LOX and eLOX-3 are engaged in the synthesis of the cornified envelope (CE) through the enzymatic synthesis of lipid oxide products in the epidermis to maintain the skin barrier and reduce transepidermal water loss (TEWL) (Krieg and Furstenberger, 2014)