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In this Review, Roland Staud and Miguel E Rodriguez discuss the abnormalities of pain processing that occur in these patients, focusing on the role of deep-tissue nociception, peripheral and central pain processing, temporal summation of pain (or wind-up) and central sensitization.
Berberine, found in a variety of plants, is used in TCM, Ayurveda, and other medicinal traditions to treat infections, digestive conditions, and inflammatory disorders.

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