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doi: 10.1016/j.jhep.2024.04.031

showed that, in mice, thiamine deprivation for 14 days led to different degrees of enzymatic deficiencies when testing for TKT, PDH, and KGDH activities in the cortex and hippocampus ( In cases of severe thiamine deficiency, however, a broad enzymatic deficiency encompassing all three mitochondrial TPP-dependent enzymes would be expected to result in symptoms similar to those of the genetic disorder dihydrolipoamide dehydrogenase (DLDD) deficiency (OMIM 246900)

These interconnected mechanisms further illuminate the complexity of ferroptosis regulation and underscore the essential role of lipid peroxidation in its execution

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Congenital Lesions Introduction Developmental anomalies occasionally occur in the liver of rodents