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( g-h ) Volcano plot of significantly changing metabolites between day 14 BCS-treated ( g ) or SLC31A1-KO ( h ) SEM cells, with amino acids highlighted in pink

Long Y, Wang X, Youmans DT, Cech TR

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300 , L295304, doi: 10.1152/ajplung.00134.2010 (2011)

However, under certain circumstances, autophagy can consume too much cytoplasmic material and promote apoptosis or necrosis, ultimately leading to autophagic cell death (Mario et al., 2014)