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Combined genetic deletion of GDF15 and FGF21 has modest effects on body weight, hepatic steatosis and insulin resistance in high fat fed mice

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Advancements in single-cell RNA sequencing have characterized previously unrecognized spatial heterogeneity and immune functions of stromal cells in the lymph nodes (114, 122, 123, 125, 130, 131), suggesting that the disintegration of the highly organized stromal cell structure will impair the anti-cancer immune responses (132)

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In autophagy, anti-apoptotic proteins, such as Bcl-xL and XIAP are also degraded, thus promoting the removal of tumor cells by cytotoxic lymphocytes and NK cells through the Granzyme pathway [86]