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Ventromedial and orbital prefrontal neurons differentially encode internally and externally driven motivational values in monkeys

The common biologic evergreening sequence runs as follows: the originator files a next-generation formulation patent (covering a higher-concentration or modified-excipient version) approximately five to eight years after initial approval, then launches the new formulation commercially and uses formulary contracting and rebate structures to shift patient volume away from the original formulation toward the new one

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