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Primero, NAD+ funciona como coenzima redox directa: transporta electrones en la fosforilacin oxidativa (OXPHOS) y sirve de sustrato consumible para las PARP (reparacin de ADN) y las sirtuinas SIRT1-7, deacetilasas dependientes de NAD+ que regulan expresin gnica, biognesis mitocondrial y respuesta al estrs

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Predrag Sikirics group (School of Medicine, University of Zagreb, 1991 ) Most common experimental dose in animal studies: 10 g/kg intraperitoneally or per os, daily Standard targeted pathways: VEGFR2 angiogenesis, NO synthase , 5-HT2A serotonin receptor, dopamine D2 receptor Clinical program in Croatia halted at Phase 2 (Crohns disease) WADA Prohibited List: added in 2022 to category S0 (Non-Approved Substances) Reference sources (PubMed) Sikiric P

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