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GDNF growth factors BBB blood- brain barrier permeability the invention provides small molecule mimetics (mimic) of the growth factor "hepatocyte growth factor (HGF) that are orally active, display profound growth factor activity, and are inexpensive to synthesize

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Alternatively, or in addition, this may be its essential penetration of both the epineurium and neuronal membrane during the action for the time that a local anesthetic remains near neural fibers