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This phenomenon, sometimes called tolerance or tachyphylaxis, is not well-studied specifically for semaglutide, but it is reported frequently in practice
[DOI] [PubMed] [Google Scholar] 131.Ahmed F.A., Hegazy K., Chaudhary P., Sharma S.C

Patients seeking weight management support should consult their GP for referral to NHS weight management services, dietitians, or specialist obesity clinics where appropriate
It imitates a hormone called glucagon-like peptide-1 (GLP-1)

Why Do Vitamin B Supplements Turn Urine Yellow
