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Data Availability Statement No primary research results, software or code have been included and no new data were generated or analysed as part of this review.

Concentrate Ratios (normalised to 100g of final cosmetic product) Desired % GHK-Cu 10% GHK-Cu Concentrate (g) Weight of your cosmetic product (g) 10% GHK-Cu Concentrate (mL) 0.1 1 99 1 0.25 2.5 97.5 2.4 0.5 5 95 4.9 1 10 90 9.7

420 One study found that in RA, fat mass and obesity-associated protein-cytidine/uridine monophosphate kinase 2 axis induced mtDNA expression and mediated the cGAS-STING pathway, enhancing synovial inflammation

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