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Inherited disorders in the conversion of methionine to homocysteine

The first successful pediatric LT was performed by Thomas Starzl in 1967 on a child with biliary atresia (BA)

This dual mechanism is what makes tirzepatide more effective than single-agonist medications

However, optimal doses appear tissue- and application-specific, with lower doses often sufficient for gastrointestinal applications while musculoskeletal injuries may benefit from higher dosing

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