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Nrf2 deficiency is frequently associated with pathological inflammatory states and increased vulnerability to stressors, while Nrf2 activation, through natural or synthetic compounds, offers promising therapeutic potential for mitigating inflammation and alleviating symptoms in various skin inflammatory disorders

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To date, pharmacotherapy remains the mainstay for improving the quality of life in PD patients

Glesatinib exhibits antitumor activity in lung cancer models and patients harboring MET exon 14 mutations and overcomes mutation-mediated resistance to type I MET inhibitors in nonclinical models