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The appearance of drusen, typically following the formation of BLamD, further disrupts RPE organization, placing both mechanical and physiological stress on the surrounding RPE cells, which results in cell death [29]

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10.1046/j.0960-7412.2001.01231.x Plant J

Germain et al., 2017

Without a caloric deficit to force the body to oxidize those fatty acids as fuel, they circulate briefly and are re-stored