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Transition safety protocol From 10mg/ml to 20mg/ml: Cut your unit draw in half
USA 112 , E63016310 (2015)

[PMC free article: PMC2746924] [PubMed: 19661457] 13

Circulating Fe 3+ enters cells with the assistance of transferrin and subsequently converts to Fe 2+ ( 2+ can catalyze the generation of metabolically toxic reactive oxygen species and phospholipid peroxide through the Fenton reaction, leading to cell damage or death (Figure 4)

Despite promising preclinical results for RITs, the small size of clinical trials performed to date has limited interpretation of the results