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Proc Natl Acad Sci U S A 114: E3233E3242, 2017

The most common early side effects of semaglutide, tirzepatide, or retatrutide include: Nausea or bloating Constipation Fatigue or low energy Mild dehydration Each of these symptoms can make physical intimacy less appealing

Generating sufficient safety evidence would require large-scale clinical trials involving thousands of participants

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