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Under hypoxic conditions, LPA increases cytoplasmic PLA2 activity via the HIF-1 pathway, promoting invasion toward collagen I and enhancing metastasis in vivo
tumor suppressors and apoptosis genes were under-expressed

Pharm Biosci J

In contrast, patients with Wilson disease experience copper dysregulation due to mutations in the ATP7B gene, which encodes a copper-transporting ATPase [18-27]
