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This has been confirmed in experimental studies on NSCLC cell lines, including A549 and H1299, where treatment with rhamnetin resulted in elevated levels of cleaved caspase-3, caspase-9, and PARP [89, 101]

Results Deficiency of USP7 impairs human terminal erythroid differentiation To explore the roles of deubiquitylases during erythropoiesis, we first analyzed the expression patterns of deubiquitylases in human erythroblasts at different stages of differentiation from our RNA-sequencing data.2 Figure 1A shows the expression patterns of USP family members and reveals that the expression levels of USP7 are significantly increased during erythropoiesis

Ouyang J, Cai Y, Song Y, Gao Z, Bai R, Wang A

Oxidative stress can lead to RPEC loss, causing photoreceptor degeneration in AMD (220)

W.ThompsonJ