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Thus, it failed

It progresses to form tender or deep-seated nodules, which expand and coalesce to form large painful abscesses

10.1111/j.1365-313X.2010.04371.x 36 Diaz-VivancosP.WolffT.MarkovicJ.PallardoF

Notably, hypoxic conditions within the TME further amplify glycolytic flux through hypoxia-inducible factor 1 (HIF-1)mediated transcriptional activation of glycolysis-related genes, thereby establishing a metabolic landscape that favors HCC survival and progression [35,36,43,44] [Figure 1]

Cochrane Database of Systematic Reviews, (3), CD004125
