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Reduced arginine and elevated ornithine levels in the tumor microenvironment impair CD8+ T-cell function, ultimately leading to tumor progression

Product Information Chemical Data Analyte Name Glutathione (glycine-13C2,15N) Trifluoroacetate Salt Molecular Formula C8 13C2 H17 N2 15N O6 S x C2 H F3 O2 Molecular Weight 310.3011402 SMILES O[13C]([13C]([H])([15N](C([C@@H](NC(CC[C@H](N)C(O)=O)=O)CS)=O)[H])[H])=O.FC(F)(C(O)=O)F InChI InChI=1S/C10H17N3O6S.C2HF3O2/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16;3-2(4,5)1(6)7/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19);(H,6,7)/t5-,6-;/m0./s1/i3+1,8+1,12+1

Furthermore, aberrant vasculature promotes the Warburg effect, which accumulates lactic acid within the TME, which is another important cause of suppressed anticancer immunity [36,68]

doi: 10.1016/j.bbamem.2006.09.024 125

Claims (15) Priority Applications (1) Applications Claiming Priority (2) Publications (2) Family ID=9369324 Family Applications (2) Family Applications After (1) Country Status (10) Cited By (6) Families Citing this family (1) Citations (1) Family Cites Families (5) 1988 1988-08-12 FR FR8810886A patent/FR2635264B1/en not_active Expired - Fee Related 1989 1989-08-01 CA CA000607172A patent/CA1341260C/en not_active Expired - Fee Related 1989-08-10 DE DE198989402257T patent/DE354848T1/en active Pending 1989-08-10 ES ES89402257T patent/ES2043062T3/en not_active Expired - Lifetime 1989-08-10 EP EP89402257A patent/EP0354848B1/en not_active Expired - Lifetime 1989-08-10 PT PT91430A patent/PT91430B/en not_active IP Right Cessation 1989-08-10 DE DE8989402257T patent/DE68903448T2/en not_active Expired - Fee Related 1989-08-10 AT AT89402257T patent/ATE82122T1/en not_active IP Right Cessation 1989-08-10 EP EP89909580A patent/EP0428608A1/en active Pending 1989-08-10 WO PCT/FR1989/000419 patent/WO1990001316A1/en not_active Ceased 1989-08-10 JP JP1508982A patent/JP2785989B2/en not_active Expired - Lifetime 1991 1991-09-27 GR GR90300149T patent/GR900300149T1/en unknown 1992 1992-12-21 GR GR920403006T patent/GR3006598T3/el unknown