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Taken together, these findings extend the H 2 O 2 -decomposing activity of KDS12025 beyond the brain, illustrating its capacity to target systemic inflammation-associated oxidative stress and highlighting its potential as a broad-spectrum therapeutic for diverse H 2 O 2 -driven diseases

Cell chemotaxis and cytokine-cytokine receptor interactions are common knowledge that participate in inflammation response in asthma

LTR signaling is important for secondary and ectopic/tertiary lymphoid tissue organization, a typical manifestation of B cell hyperactivation [59]

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GPX5 is described in the epididymis as a secreted protein that contains cysteine (Cys) in the active center instead of Sec, GPX5 is the first discovered Cys-based superfamily member, also known as epididymal GPX (EGPX), which has now been shown to play a role in protecting mouse sperm from hydrogen peroxide toxicity (Zhang et al., 2008