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10.1016/j.parkreldis.2003.07.001 Parkinsonism Relat Disord

Apply the patch to clean, dry skin before retiring

By assisting in the transport of fatty acids for energy production, L-Carnitine may help individuals maximize the benefits of a healthy diet and regular exercise program
Such suboptimal measures have led to delayed diagnose and even misdiagnoses, particularly for high-functioning autism [8,9]

I have dry-combo sensitive skin and found the cream alone was enough for my skin during the night (after toner and serum)