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This design had the lowest mintage of all five 2017 America the Beautiful quarters, making it relatively scarcer than its counterparts

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[DOI] [PMC free article] [PubMed] [Google Scholar] 37.Danilkovitch-Miagkova A., Zbar B

Sirtuins, particularly SIRT1, need NAD+ as a cofactor for protein deacetylation

The amber or clear glass of the vial provides some protection, but minimizing light exposure extends effective shelf life
