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glutathione essential cofactor to process vitamin b12 Cofactors: How They Protect Your Bones And How Get Them Vitamin B12
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Ganapathy V, Thangaraju M, Prasad PD, Martin PM, Singh N

The medication (morphine (16 mg/kg s.c.), the tested agents (gastric pentadecapeptide BPC 157 (10 pg, 10 ng and 10 g/kg i.p.), naloxone (10 mg/kg s.c.), haloperidol (1 mg/kg i.p.) or saline (5 ml/kg i.p.) was given accordingly at either 30 min, 20 min or 10 min before the first assessment (time "0"), and subsequently, the mice were assessed at 15, 30, 45, 60, 90, 120, 150 and 180 min intervals (time "+")
M., Holmes, L., Raines, J., Orbell, S., & Rieger, G

Holers VM, Demoruelle MK, Kuhn KA, Buckner JH, Robinson WH, Okamoto Y, et al

This is also known as sleep deficit or sleep debt