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Ltd., and nude mice (8-week-old males) were purchased from Beijing Viton Lihua Laboratory Animal Technology Company

It is not surprised that if we raised cytosolic GSTP level through GSTP plasmid transfection or treated mice with GSTP protein, the excessive inflammatory responses and mortality rate of CLP-induced sepsis were significantly reduced

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Nevertheless, contemporary investigations have indicated that APOE stimulates the PI3K/AKT signaling cascade to suppress ferroptosis, consequently hindering iron-catalyzed lipid peroxidation ( 9 Targeting ferroptosis to treat AD Up to now, drug-based interventions crafted for Alzheimers pathology remain non-remedial, yet they succeed in easing the clinical manifestations of the disorder (Long and Holtzman, 2019)