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L-F001 L-F001 (Figure 6B), a multifunctional fasudil-ALA dimer, effectively prevents paraquat-induced apoptosis by modulating GRP78 and CHOP expression, alleviating mitochondrial dysfunction, and reducing endoplasmic stress in PC12 cells [80]
Compared with synthetic drugs, Scrophularia radix , as a natural extract, offers the advantage of low toxicity
Cycling theoretically prevents tolerance and allows natural enzyme function to reset
