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Interestingly, these aforementioned enzymes have been reported to be modified by lysine lactoylation (35)

Biochem Biophys Res Commun 2004;314:92530

Mar 31 2021 Dalbeni et al., Nutrition, Metabolism and Cardiovascular Diseases, doi:10.1016/j.numecd.2020.12.005 Excessive vitamin B12 and poor outcome in COVID-19 pneumonia Prospective study of 49 hospitalized COVID-19 patients in Italy showing higher vitamin B12 levels associated with worse outcomes

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Metabolic unpredictability: Simultaneously altering multiple metabolic pathways incretin signalling, glucagon activity, and NAD+ metabolism without clinical oversight introduces unpredictable physiological consequences
