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In agreement, glycogen synthase kinase-3, which demonstrates increased kinase activity in AD, is able to directly phosphorylate Nrf2, thereby inducing its nuclear efflux

Figure 2 Carnitine, functioning in the mitochondrial fatty acid oxidation, also plays an important role in regulating the ratio of free coenzyme A (CoA) to acyl-CoA and in the removal of excessive acyl groups ( Acetyl-L-Carnitine and Physiological Function Of the ACs in living organisms, LAC, as the most widely studied endogenous short-chain ACs, has the highest content of ACs and participates in cell anabolism and catabolism pathway ( Carnitine and Depression Increasing data seem to prove the hypothesis that carnitine levels are related to the progression of depression (Studies are summarized in Tables 1, 2)

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Alm disso, deve-se ter em mente que o mecanismo de fadiga ainda no totalmente compreendido e a falta de glicognio certamente no o nico fator envolvido