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61 In practice, some patients may be able to switch to very high dose (ie, 2000 mcg daily) oral supplementation instead of continuing parenteral administration, but it is impossible to predict in whom this can be done safely, and many are at risk of worsening symptoms which may become permanent

This preparation contains 5 mg of lyophilized AOD-9604 supplied in a sealed research vial

Parenteral cyanocobalamin (J3420) or hydroxocobalamin administration receives favourable coverage because intrinsic factor deficiency prevents oral absorption

Inject the total volume of Vitamin B12 under the skin

Elimination half-life is about 1-2 hrs