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Specifically, both SREBP-1 isoforms (SREBP-1a and SREBP-1c) are involved in the regulation of fatty acid synthesis, whereas SREBP-2 is mainly involved in the regulation of cholesterol biosynthesis [94]

AAV-shChac2 delivery alleviated systemic inflammation and improved metabolic outcomes in diabetic mice Based on the well-established clinical and experimental association between periodontitis and diabetes, 41,42,43,44,45,46,47 diabetes was used as a representative comorbidity model to assess the systemic impact of periodontitis-induced neutrophil reprogramming

(Please note that I am presenting a tremendous over-simplification about genetics here

doi: 10.1083/jcb.201701085

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