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Description
For each eligible study, two authors (MM and AN) independently extracted data, which was then reviewed by a third author (JV) using a piloted spreadsheet, in accordance with Cochrane Collaboration guidelines ( Where relevant data were missing, attempts were made to contact corresponding authors

swelling of the ankles or feet

A study in the Journal of the American Geriatrics Society showed benefits

The optimal administration route in humans has not been definitively established through clinical trials

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