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EGF is a growth factor that plays an important role in the regulation of cell growth, cell proliferation, and differentiation

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LongTerm Potentiation Depends on Release of DSerine From Astrocytes. Nature 463: 232236

In contrast, stressinduced Nrf2 targets are rather involved in antioxidant defense, xenobiotic detoxification, inflammation and immunity regulation, DNA repair, and prevention of apoptosis

These areas have higher concentrations of beta-3 adrenergic receptors, which are the primary target of the peptides mechanism
