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Future trials must incorporate robust biomarkerssuch as NFB activation levels, tumor suppressor gene methylation status, or immune cell cytotoxicityto identify which patients are most likely to benefit

Laser therapy works by delivering focused light energy to the skin, which stimulates collagen production , improves skin texture , and breaks down excess melanin responsible for dark pigmentation

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One potential cause is when antibiotics or antimicrobials kill spirochetes, they break apart and release inflammatory substances such as cytokines into the bloodstream, triggering a strong immune response