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In this Phase 1b study, NSI-189, a novel chemical entity that stimulated neurogenesis in earlier studies, was well tolerated, and administration of 40 mg doses of NSI-189 Q24H, Q12H and Q8H for 28 days resulted in accumulation consistent with the mean t of 17.420.5 h, with steady state being reached after 96120 h, consistent with the t and independent of the dosing regimen

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