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The manuscript highlights how DDSsincluding stimuli-responsive nanoparticles, targeted ligands, and biodegradable carriersenhance solubility, bioavailability, and tissue-specific delivery of urate-lowering agents (e.g., allopurinol and febuxostat) and anti-inflammatory therapies (e.g., colchicine and IL-1 inhibitors) (Liu S
Liposomal or sublingual Glutathione forms are more effective, but the body often produces more lasting results when supported with NAC or GlyNAC supplementation
these changes collectively contribute to increased epileptiform activity 320,321
Continuing through this plateau typically leads to resumed improvement
Di Nicola, M
