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Here the authors show that the enzymatic activity of glutaredoxins requires two distinct glutathione interactions sites, one recognizing the glutathione disulfide substrate and one activating glutathione as a reducing agent.

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Upon receptor activation, intracellular signalling cascades involving phospholipase C, inositol triphosphate, and calcium mobilisation are initiated, leading to pulsatile release of growth hormone independent of hypothalamic growth hormone releasing hormone (GHRH) stimulation

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