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Moreover, various transcription factors such as specificity protein 1 (SP1), activator protein 1 (AP-1), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) and GATA1 were reported to play an important role in the regulation of GSTP1 expression ( Figure 1

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Note: increlex (mecasermin) is FDA-approved recombinant native IGF-1 for severe primary IGF-1 deficiency distinct molecule from LR3

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In all early-stage clinical studies of IGF-1R therapeutics, there were always a few patients for whom there was substantial and long-lasting benefit, whetting the appetite for additional study